New Hampshire have not yet disclosed the number of people who died in the horror crash.
Emergency services rushed to the scene, with footage showing the multi-family home engulfed in flames following the wreck.
Locals said their homes shook as the plane collided with the building, with eight residents able to evacuate in time while flames ripped through the home.
A tenant in the building, Robin Guimond, told WCVB: "It was very scary, I mean, I was sitting in the chair and I heard the big bang and then the house shaking".
Scott Gauthier, another resident in the apartment block, said: "I just grabbed what I needed to grab